Hilary, 25, presents with 3 days of progressively swollen, painful red eye, on a background of recent “cold and flu” complicated by sinusitis. She has blurring of her vision and occasionally sees double. She has a fever and has felt “like Ive been run over by a truck” for the past few days.

What is the most likely diagnosis?

  1. Orbital Cellulitis

What are some differentials for this presentation?

  1. Orbital Cellulitis
  2. Pre-septal cellulitis
  3. Cavernous Sinus Thrombosis
  4. Allergic Conjunctivitis
  5. Viral conjunctivitis
  6. Angioedema

What are some important questions to ask Hilary about her recent health?

  1. upper respiratory tract infections
  2. sinusitis
  3. dental surgery
  4. prior surgery or trauma
  5. immune compromise

What are the key features of history you would inquire about to find a cause for Hilary’s symptoms?

  1. Massively swollen eye
  2. Red eye
  3. Visual disturbance
  4. Diplopia
  5. Blurry vision
  6. Fever
  7. Malaise
  8. Pain on eye movement

What are the key features of examination that would assist you in finding a cause for Hilary’s symptoms?

  1. Fever T > 37.5
  2. Severe Malaise
  3. Eyelid oedema (71% of people)
  4. signs limited to upper eye lid and not extending to brow
  5. Eye Erythema
  6. Chemoses
  7. Decr VA (14% of people)
  8. Proptosis ** (69% of people)
  9. Gaze restriction ** (59% of people)
  10. Diplopia (6% of people)
  11. Visual blurring
  12. Pain on eye movement (52% of people)
  13. RAPD (5% of people)
  14. Papilloedema / Neuritis

What are the key features of examination in pre-septal cellulitis?

  1. Fever
  2. Eyelid oedema – may extend to brow
  3. Erythema
  4. Chemoses
  5. Ptosis
  6. No Orbital signs

 What are the key features of examination in Cavernous Sinus Thrombosis?

  1. fever
  2. headache
  3. mental status changes
  4. nuchal rigidity
  5. chemosis (red and bulging conjunctiva)
  6. proptosis
  7. impaired extraocular muscle motility, usually starting with lateral gaze

 What is the most important initial management step to perform for Hilary?

  1. Immediate Referral to ED

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