Features of acanthosis nigricans

Hyperpigmented, hyperkeratotic areas

symmetrically distributed

Hyperkeratotitis

On axillae, groin, cub foss, pop foss

Multiple skin tags are associated

Causes of acanthosis nigricans

Insulin resistance

Diabetes

Internal malignancy – Maligancies of large and small bowel, ovaries, lung, breast, prostate, Stomach adenocarcinoma

Rare genetic disorders

Hypothyroidism

Polycystic ovaries

Oestrogens

Steroids

Nicotinic acid

Management of Acanthosis Nigricans

Weight loss an reverse changes in obesity

Refer non-obese patients